Castelmuzio is a village in Tuscany, central Italy, administratively a frazione of the comune of Trequanda, province of Siena. At the time of the 2001 census its population was 265. Popolazione residente - Siena (dettaglio loc. abitate) - Censimento 2001 , Istat.

Castelmuzio is about 55 km from Siena and 8 km from Trequanda.

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