The following is a list of sports cards that have sold for an inflation-adjusted price of over $500,000. The list is ordered by inflation-adjusted value (in bold) in millions of United States dollars.

This list includes only the highest price paid for a given card and does not include separate entries for individual copies of the same card or multiple sales prices for the same copy of a card. Thus, for example, the T206 Honus Wagner is represented on this list by one particular card's 2021 sale and does not include the same card's 2012 sale for $1.2 million or the Jumbo Wagner and its $3.12 million sale price.

Cards are evaluated by third-party services, most often Professional Sports Authenticator (PSA), Beckett Grading Services (BGS), or Sportscard Guaranty Corporation (SGC), and given a grade on a ten-point scale based on condition.

The first sports card to sell for one million dollars was a T206 Honus Wagner which sold for $1,265,000 at auction in 2000 ().

The images below do not necessarily represent the individual specimen sold but are representative of the given cards.