Senator Guthrie may refer to:
Members of the Australian Senate James Francis Guthrie (1872–1958), senator for Victoria Robert Storrie Guthrie (1857–1921), senator for South Australia
United States state senate members Brett Guthrie (born 1964), Kentucky State Senate Brian Guthrie fl. 2020s), Oklahoma State Senate James Guthrie (Kentucky politician) (1792–1869), Kentucky State Senate Jim Guthrie (politician) (born 1955), Idaho State Senate