Robert P. Griffin (1923–2015) was a U.S. Senator from Michigan from 1966 to 1979. Senator Griffin may also refer to:
AJ Griffin (politician) (fl. 2010s), Oklahoma State Senate Anthony J. Griffin (1866–1935), New York State Senate Ben Hill Griffin Jr. (1910–1990), Florida State Senate Floyd Griffin (born 1944), Georgia State Senate Gail Griffin (fl. 1990s–2010s), Arizona State Senate James D. Griffin (1929–2008), New York State Senate James W. Griffin (1935–2023), Iowa State Senate John K. Griffin (1789–1841), South Carolina State Senate John Griffin (Allegany County, New York) (1770s–1846), New York State Senate Michael Griffin (Indiana politician) (fl. 2020s), Indiana State Senate Michael Griffin (Wisconsin politician) (1842–1899), Wisconsin State Senate