γ-Carboline, or gamma-carboline, also known as 5H-pyrido[4,3-b]indole is a nitrogen-containing tricyclic heterocycle. A large number of derivatives are known with varying pharmacological properties. Tetrahydrogenated γ-carbolines like 2MePI are serotonin 5-HT2A receptor modulators. The pyridopyrroloquinoxalines are cyclized γ-carbolines and include serotonergic psychedelics like IHCH-7113, non-hallucinogenic serotonin 5-HT2A receptor agonists like IHCH-7079, IHCH-7086, and ITI-1549, and serotonin 5-HT2A receptor antagonists like lumateperone (ITI-007).
See also β-Carboline Tiflucarbine
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