The 1978 Penn Quakers football team was an American football team that represented the University of Pennsylvania during the 1978 NCAA Division I-A football season. Penn finished last in the Ivy League.

The team played its home games at Franklin Field adjacent to the university's campus in Philadelphia, Pennsylvania.

History In its eighth year under head coach Harry Gamble, the team compiled a 2–6–1 record and was outscored 187 to 139. Tom Roland and Boris Radisic were the team captains.

Penn's 1–5–1 conference was the worst in the Ivy League standings. The Quakers were outscored 154 to 99 by Ivy opponents.

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