James W. Huffman (1894–1980) was a U.S. Senator from Ohio from 1945 until 1946. Senator Huffman may also refer to:
Bill Huffman (1924–2019), Michigan State Senate Charles Solomon Huffman (1865–1960), Kansas State Senate Joan Huffman (born 1956), Texas State Senate Matt Huffman (born 1960), Ohio State Senate Steve Huffman (Ohio politician) (born 1964), Ohio State Senate