Twala is a surname. Notable people with the surname include:
Mary Twala (1939–2020), South African actress Musawenkosi Twala (born 2000), South African cricketer Sello Chicco Twala (born 1963), South African musician and producer Shado Twala (born 1958), South African radio DJ, journalist, entrepreneur, and radio and television producer William Twala (born 1990), South African footballer