Molefe is a surname. Notable people with the surname include:
Brian Molefe, South African businessman and politician California Molefe (born 1980), Botswanan runner Kgaudisa Molefe (born 2000), South African cricketer Matee Molefe, South African sailor Popo Molefe (born 1952), South African politician Thabang Molefe (born 1979), South African football player
Given name Molefe Lekoekoe, Lesothan football player Molefe Pheto (born 1935), South African musician