Regina Isecke (5 January 1953 – 26 June 2015) was a German wheelchair tennis player who competed in international level events. She was known as a pioneer in wheelchair tennis in Germany and was the German Wheelchair Tennis Association's president for many years until her death.
Isecke was involved in an accident in 1971 resulting in a spinal cord injury and paraplegia, she was previously a wheelchair basketball player and a para table tennis player before switching to wheelchair tennis.
A street in Junkersdorf, Cologne is named after her, Regina-Isecke-Straße, in 2018.
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