Senator Middleton may refer to:
Andrew C. Middleton (1824–1909), New York State Senate Clyde Middleton (1928–2019), Kentucky State Senate Henry Middleton (governor) (1770–1846), South Carolina State Senate Henry Middleton (1717–1784), South Carolina State Senate Mayes Middleton (born 1981), Texas State Senate Thomas M. Middleton (born 1945), Maryland State Senate