Calame is a surname. Notable people with the surname include:
Alexandre Calame (1810–1864), Swiss painter André Calame, Swiss figure skater Byron Calame (born 1939), American journalist Claude Calame (born 1943), Swiss writer on Greek mythology Geneviève Calame (1946–1993), Swiss pianist, music educator and composer Ingrid Calame (born 1965), American artist Marie-Anne Calame (1775–1834), Swiss miniaturist and philanthropist educator