Papaleo is a surname. Notable people with the surname include:
Carolina Papaleo (born 1969), Argentine actress Joaquín Papaleo (born 1994), Argentine footballer Joe Papaleo (born 1961), American soccer goalkeeper Joseph Papaleo (1925–2004), Italian American novelist and academic Lawrence Papaleo (born 1989), American soccer coach and former player Raúl Papaleo (born 1971), Puerto Rican beach volleyball player Rocco Papaleo (born 1958), Italian actor, film director and singer