Masisi is a town in the Democratic Republic of the Congo.
Masisi may also refer to:
Mokgweetsi Masisi, the fifth president of Botswana Edison Masisi, a diplomat and politician from Botswana and the father of Mokgweetsi Masisi Neo Masisi, the First Lady of Botswana and wife of Mokgweetsi Masisi Love Masisi, Dutch drag queen Masisi Territory, a territory around Masisi in the Democratic Republic of the Congo