Küffner or Kuffner is a surname. Notable people with the surname include:
Aaron Kuffner (born 1975), American artist Andreas Kuffner (Luftwaffe), recipient of Knight's Cross of the Iron Cross Andreas Kuffner (rower) (born 1987), German rower James Kuffner (born 1971), Robotics Professor and Researcher Joseph Küffner (Kueffner, 1776–1856), German musician and composer Moriz von Kuffner (1854–1939), Jewish-Austrian industrialist, art collector, mountaineer and philanthropist Ryan Kuffner (born 1996), Canadian ice hockey player William Kueffner (1840–1893), officer in the Union Army during the American Civil War