John Wilkie (1860–1934) was an American journalist and Chief of the United States Secret Service.
John Wilkie may also refer to:
John Wilkie (canoeist) (born 1977), Australian canoeist John Wilkie (footballer) (1947–2023), Scottish footballer John Wilkie (cricketer) (1877–1963), New Zealand cricketer
See also Jack Wilkie (footballer, born 1876) (fl. 1890s), Scottish footballer with Partick Thistle, Rangers, Blackburn Rovers John Wilke (1954–2009), American investigative reporter John C. Willke (1925–2015), American medical doctor, author, and anti-abortion activist