The name Wicomico may refer to the following:
The Wicocomico or Wicomico people, an Algonquian-speaking Native American tribe, part of whom lived in the Tidewater region of Virginia Wicomico River (disambiguation), several rivers tributary to the Chesapeake Bay watershed Wicomico County, Maryland , formerly USS Choctaw, a yard tug in the United States Navy Wicomico High School