Muhlenberg is a surname. Notable people with the surname include:
Bill Muehlenberg (born 1953), Australian blogger Edward D. Muhlenberg (1831–1883), American civil engineer and Civil War officer Francis Swaine Muhlenberg (1795–1831, American political leader Franz Mühlenberg (1894–1976), German politician Frederick Muhlenberg (1750–1801), first Speaker of the United States House of Representatives Frederick Augustus Muhlenberg (1887–1980), founder of Muhlenberg Greene Architects and an American military and political leader Frederick Augustus Muhlenberg (educator) (1818–1901), president of Muhlenberg College Gotthilf Heinrich Ernst Muhlenberg (1753–1815), American clergyman and botanist Henry Muhlenberg (1711–1787), German Lutheran clergyman and patriarch of the Muhlenberg family Henry A. P. Muhlenberg (1782–1844), early American political leader and diplomat Henry Augustus Muhlenberg (1823–1854), American politician Henry Augustus Muhlenberg (1848–1906) of Reading, Pennsylvania Henry Muhlenberg (mayor), of Lancaster, Pennsylvania Peter Muhlenberg (1746–1807), clergyman and major general of the Continental Army William Augustus Muhlenberg (1796–1877), American philanthropist and Protestant Episcopal clergyman