John C. Calhoun (1782–1850) was a U.S. senator from South Carolina from 1845 to 1850. Senator Calhoun may also refer to:
Bob Calhoun (1937–2020), Virginia State Senate Charles Calhoun Jr. (1931–2014), Texas State Senate James Calhoun (politician, born 1802) (1802–1852), Georgia State Senate Riemer Calhoun (1909–1994), Louisiana State Senate William B. Calhoun (1796–1865), Massachusetts State Senate