Charles Guy may refer to:
Charles A. Guy (died 1985), American newspaper owner and editor Charles H. Guy (1924–2010), American football and lacrosse player and coach Charles L. Guy (1856–1930), American lawyer and politician from New York Charlie Guy (1896–1974), American football player
See also Guy (surname) Charles Guy Briggle (1883–1972), United States district judge Charles Guy Parsloe (1900–1985), British historian, writer and Liberal Party politician