Isham Talbot (1773–1837) was a U.S. Senator from Kentucky from 1815 to 1819 and 1820 to 1825. Senator Talbot may also refer to:
John C. Talbot (1784–1860), Maine State Senate Kirk Talbot (born 1969), Louisiana State Senate Matthew Talbot (1767–1827), Georgia State Senate Ray Herbert Talbot (1896–1955), Colorado State Senate
See also Albert G. Talbott (1808–1887), Kentucky State Senate