Charles Grayson could refer to:
Charles Grayson (writer) (1903-1973), American screenwriter and novelist Charles E. Grayson (1910-2009), American radiologist and archer Charles F. Grayson, alias of Moody Merrill (1836–1903), American politician, businessman, and fugitive Trey Grayson (Charles Merwin Grayson III) (born 1972), American politician