Sofronie may refer to:
Name Sofronie of Cioara, Romanian Orthodox saint Sofronie Drincec (born 1967), Romanian bishop Sofronie Vârnav, Moldavian and Romanian political figure, philanthropist, collector, and Orthodox clergyman Sofronie Vulpescu (1856 – 1923), Romanian cleric
Surname Nicoleta Daniela Șofronie (born 1988), Romanian artistic gymnast
See also Sofron Sofronije Sophronia (disambiguation) Sophronius (disambiguation)