Nyame is both a given name and surname. Notable people with the name include:

Jayden Antwi-Nyame (born 1998), English footballer Jolly Nyame (born 1955), Governor of Taraba State in Nigeria Victoria Nyame (died 1980), Ghanaian politician Nyame Brown, artist from San Francisco Omar Nyame (born 1998), English television personality

See also Nyam (disambiguation)