The 1960 Louisville Cardinals football team was an American football team that represented the University of Louisville as an independent during the 1960 college football season. In their 15th season under head coach Frank Camp, the Cardinals compiled a 7–2 record.

The team's statistical leaders included Ernie Green with 441 rushing yards and John Giles with 436 passing yards.2019 Media Guide, p. 177 and 182.

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