Tolomeo (Italian, 'Ptolemy') is an opera seria by Handel.
Tolomeo may also refer to:
Ptolemy (name), including a list of people named Tolomeo Tolomeo (horse) (1980 – circa 2000), a Thoroughbred racehorse Tolomeo desk lamp, an iconic Italian desk lamp design
See also Ptolemy (disambiguation) Tolomeo e Alessandro, an opera by Scarlatti