The COVID-19 pandemic began in the U.S. state of Illinois on January 24, 2020, when a woman in Chicago, who had just returned from the pandemic's place of origin in Wuhan, Hubei, China, tested positive for the virus. This was the second case of COVID-19 in the United States during the pandemic. The woman's husband was diagnosed with the disease a few days later, the first known case of human-to-human transmission in the United States. Community transmission was not suspected until March 8, when a case with no connection to other cases or recent travel was confirmed.

In mid-March, as the number of known cases rose into the double digits, Governor J. B. Pritzker issued a disaster proclamation, the state's equivalent of a state of emergency, to respond to the crisis. The state took measures to halt the spread of the disease by closing all schools and colleges, ordering a stop to eviction enforcements, ordering all bars and restaurants closed to sit-in diners, and otherwise restricting large gatherings of people. As the virus spread further, the state enacted an even stronger shelter in place order, affecting schools and businesses across the state. At first declared between March 21 and April 7, the order was later extended until April 30, then May 29.

During December 2020, Illinois experienced the second highest number of deaths per week, ranking fifth per capita, which spurred calls for Governor Pritzker to respond to the pandemic more aggressively. In January 2021, Illinois had the fifth highest number of confirmed cases in the United States.

, Illinois had administered 11,049,665 COVID-19 vaccine doses, and 49% of the population was fully vaccinated.

Timeline

January 2020 On January 24, 2020, Illinois health officials announced the first confirmed case the novel coronavirus infection in the state of Illinois, also the second confirmed case in the United States. The case was a woman in her 60s who had returned from a December 25 – January 13 visit to Wuhan, China, the place of origin of the outbreak, where she had frequently visited a hospitalized relative and other relatives with respiratory illnesses. She began to experience symptoms after returning to Chicago, and was isolated at St. Alexius Medical Center in the Chicago suburb of Hoffman Estates.

On January 30, the Centers for Disease Control and Prevention (CDC) confirmed that the first known human-to-human transmission in the U.S. of the SARS-CoV-2 virus (then known as 2019-nCoV) had occurred in Chicago. According to the CDC, the woman who was the first Illinois case had transmitted the virus to her husband, who was confirmed as the second Illinois case and the sixth U.S. case after testing positive. He was isolated at the same hospital as his wife.

February 2020 On February 7, the two Illinois cases were released from the hospital and began home isolation. Both made full recoveries and were released from isolation on February 14. On February 29, a third Illinois resident tested positive for the virus in suburban Cook County.

March 2020 On March 2, a fourth case was announced by Illinois officials, the wife of the third case; she subsequently began home isolation. Other details were announced by officials: her husband had been isolated at Northwest Community Hospital in Arlington Heights since his case was reported two days earlier; both were in their 70s. The couple was possibly exposed to the virus through community transmission, with recent travel to Palm Springs. The man was later released to home isolation.

On March 5, public health officials in Chicago reported a fifth case of coronavirus in a man in his 20s. The man, a student at Vanderbilt University, had recently traveled to Italy to study abroad and returned to Illinois on a flight to Chicago O'Hare International Airport. The new case was hospitalized at Rush University Medical Center. On March 6, a sixth case was reported in Chicago. The patient, a classroom assistant in the Vaughn Occupational High School, had been on the Grand Princess cruise ship where multiple passengers had tested positive.

On March 8, a seventh case was announced in Cook County. The man in his 60s had not traveled to an area impacted by coronavirus and did not have any contact with other cases; as a result, Illinois officials reported the patient as the first evidence of community transmission within Illinois. He was also reported to be in serious condition. Additionally, a Missouri case connected to Illinois was confirmed; the patient had returned from Italy on a flight to O'Hare Airport, then took an Amtrak train to St. Louis, where she tested positive.

On March 9, four additional cases were announced in Cook County, bringing the state's total number of cases to eleven. Two of the new cases were family members of the classroom aide diagnosed on March 6; the two others included a California resident who traveled to Illinois, and a woman who had returned from an Egyptian cruise which was linked to many COVID-19 cases. In response to the growing number of cases in the state and the country, Governor J. B. Pritzker announced a disaster proclamation (a state of emergency) for the state of Illinois. On March 10, Governor Pritzker announced eight new presumptive positive cases, two of which were the first cases outside of Cook County (in Kane and McHenry Counties). These cases brought Illinois's total number of cases to 19.

On March 11, six new cases of the coronavirus were reported by officials, including the first in Lake County, bringing the total to 25. One of these cases was located at One Prudential Plaza, marking the first confirmed case in a major downtown Chicago office building. Illinois colleges and universities, such as Northwestern University and the University of Illinois, announced measures to combat the spread of the virus on their campuses through extensions of Spring Break as well as implementing online classes for part or all of the remaining semester. In response to the growing pandemic, both Former Vice President Joe Biden and Senator Bernie Sanders canceled campaign rallies planned for Illinois. Additionally, Chicago Mayor Lori Lightfoot canceled the city's annual St. Patrick's Day parade and Chicago River dyeing in response to coronavirus. On March 12, seven new cases of the coronavirus were reported by officials, including the first child who tested positive in Illinois. This brought the total to 32.

On March 13, fourteen new cases of the coronavirus were reported by officials, bringing the total to 46. Governor Pritzker announced statewide school closures beginning March 17 until March 30. Casinos statewide would close for fourteen days beginning on March 16. Additionally, the Circuit Court of Cook County announced that "no orders for an eviction or foreclosure will be entered during the 30-day period," and the Archdiocese of Chicago announced it would stop holding public Mass from March 14.

On March 14, the total number of cases in Illinois rose to 66. These included the first cases in Downstate Illinois, with patients testing positive in Woodford, Cumberland, and St. Clair Counties. A new case in DuPage County was the first Illinoisan resident of a long-term care facility to contract the virus. At O'Hare Airport, travelers returning from Europe faced enhanced screening from U.S. Customs officials due to the federal travel ban put in place the day before. The screenings led to long waits and overcrowded facilities in the airport, which both Governor Pritzker and Mayor Lightfoot harshly criticized as unsafe.

On March 15, the number of cases rose to 93. Cases were confirmed in Champaign, Clinton, Sangamon, Whiteside, and Winnebago Counties; meanwhile, Governor Pritzker ordered all bars and restaurants closed to sit-in diners. One of the cases in Sangamon County was a woman in critical condition who was hospitalized in Springfield, the state's capital. On March 16, the number of cases rose to 105, and Peoria and Will Counties confirmed their first cases. Governor Pritzker announced restrictions for public gatherings, limiting crowds to under 50 people amid growing concerns over the community spread of the virus in the state.

On March 17, the number of cases rose to 160. Officials announced the first death related to COVID-19, a woman in her 60s from Chicago; a retired South Side nurse, the woman had an underlying condition later revealed to be asthma, and died at the University of Chicago Medical Center. 22 of the new cases were confirmed at a Willowbrook nursing home, including 18 residents and four staff members; these cases were related to an initial case announced on March 14. Northwestern University, University of Illinois at Chicago, and the Illinois Institute of Technology confirmed that individuals on campus had tested positive for the coronavirus. Other new cases included employees at Midway International Airport and a Chicago Fire Department worker.

On March 18, an increase of 128 new cases brought the total number of individuals infected to 288. Kendall and Madison Counties confirmed their first cases. The new cases included 20 more individuals at the Chateau Nursing and Rehabilitation Center in DuPage County, bringing the total number of the cases at the nursing home to 42. Many students and staff members in various schools and colleges in Illinois also tested positive.

On March 19, there were 134 new coronavirus cases reported throughout the state along with three deaths which included a male in his 50s from Will County, a female in her 80s from Cook County, and an out-of-state female in her 70s who was in Sangamon County. The number of cases being reported has rapidly risen as the tests are becoming more readily available along with an increase in testing by and hospital and commercial laboratories. The health departments of Adams and McLean Counties announced that they each had a confirmed case of COVID-19.

On March 20, the Illinois Department of Public Health announced that there was an increase of 163 new cases along with the death of a woman in her 70s in Cook County. The age range for those with confirmed contraction of the COVID-19 disease was from 3 to 99. Christian County announced the first confirmed case contracted within that county. Work began on converting McCormick Place into an alternate care facility for 3,000 patients. The $15 million project was paid for by FEMA and was scheduled for completion on April 30.

On March 21, there was an increase of 168 confirmed cases and another death, a man in his 70s in Cook County. This brought the total deaths from the coronavirus disease to six. DeKalb County reported its first confirmed case. Thousands of residents of Rogers Park, Chicago participated in #chicagosingalong singing Livin' on a Prayer by Bon Jovi. Bon Jovi sent congratulations via Instagram.

On March 22, the number of confirmed cases rose by 296 bringing the number of COVID-19 cases to 1049, one an infant. Officials announced three new deaths related to the disease, two men from Cook County that were in their 80s and a McLean County woman in her 70s. Jo Daviess, Livingston, Rock Island, and Stephenson counties all reported their first case.

On March 23, officials announced another 236 cases and three more deaths, all men from Cook County, two in their 80s and one in his 90s. Monroe County announced its first case, bringing the total counties with confirmed cases to 31 of 102.

On March 24, there were 250 more confirmed cases of the coronavirus and four deaths. The dead were three from Cook County, two in their 60s and one was a male in his 50s; the fourth was a DuPage County resident in her 90s. Grundy County reported its first case.