Chassaigne is a French surname. Notable people with the surname include:
André Chassaigne (born 1950), French politician Anne-Marie Chassaigne (1869–1950), better known as Liane de Pougy, French courtesan, dancer and novelist Francis Chassaigne (1847–1922), Belgian-born French classical composer
See also Jean Bouillet de la Chassaigne (1654–1733)