Itzel or Ixchel is the Mayan goddess of midwifery and medicine. It also may refer to:

Personal name Given name Laura Itzel Castillo (born 1957), Mexican architect and politician Katia Itzel García, Mexican referee Itzel Nayeli García Montaño (born 1995), Mexican criminal and a suspected spree killer Itzel González (born 1994), Mexican footballer Itzel Manjarrez (born 1990), Mexican taekwondo athlete Itzel Reza (born 1979), Mexican sprint canoer Itzel Ríos de la Mora (born 1978), Mexican politician

Surname Adam Itzel Jr. (1864–1893), American conductor and composer Jack Itzel (1924–1966), American footballer Sandra Itzel (born 1993), Mexican actress

See also Conasprella ixchel, a marine gastropod species Ixchela, a genus of spiders