Duchess of Grafton is the title given to the wife of the Duke of Grafton. Women who have held the title include:
Isabella FitzRoy, Duchess of Grafton (1668–1723) Henrietta FitzRoy, Duchess of Grafton (1690–1726) Anne FitzPatrick, Countess of Upper Ossory (1737–1804), who was duchess from 1757 until her divorce in 1769. Elizabeth FitzRoy, Duchess of Grafton (1745–1822) Mary FitzRoy, Duchess of Grafton (1795–1873) Marie FitzRoy, Duchess of Grafton (1833–1928) Susanna FitzRoy, Duchess of Grafton (1878–1961) Lucy FitzRoy, Duchess of Grafton (1897–1943) Rita FitzRoy, Duchess of Grafton (1911–1970) Fortune FitzRoy, Duchess of Grafton (1920–2021)