Manimekalai is a Tamil epic composed by Sithalai Sattanar.

Manimekalai (alternatively spelt Manimegalai) may refer to: Manimekhala, a Hindu-Buddhist goddess Manimekalai, the titular character of the epic, first appears as the daughter of Kovalan and Madhavi in a preceding Tamil epic Silappatikaram Manimekalai (1940 film), a 1940 Indian film adaptation of the epic Manimekalai (1959 film), a 1959 Indian film adaptation of the epic Manimegalai, an Indian VJ Leena Manimekalai, Indian filmmaker, writer and actor