Mwale is an East African surname. Notable people with this surname include:
Beatrice Roseby Mwale, Malawian politician Bush Mwale (born 1993), Kenyan rugby sevens player Chanju Samantha Mwale, Malawian lawyer and army officer David Mwale (born 1999), Zambian boxer Davis Mwale (born 1972), Zambian boxer Fiona Mwale (born 1974), Malawian judge Lottie Mwale (1952–2005), Zambian boxer MacDonald Mafuta Mwale (born 1970), Malawian economist and public servant Martha Mwale (1945-2004), Malawian teacher, political prisoner, and church leader Masauso Mwale, Zambian football coach Maximo Chanda Mwale (1961–2001), Zambian comedian Temi Mwale, British social entrepreneur and campaigner Tindi Mwale (born 1986), Kenyan politician Theresa Gloria Mwale (born 1947), Malawian nurse and politician Vincent Mwale (born 1976), Zambian politician Yvonne Mwale (born 1988), Zambian singer