Penfield is a surname. Notable people with the name include:
Add Penfield (Addison Pierce Penfield, 1918–2010), North Carolina sports radio broadcaster Daniel Penfield (1759–1840), founder of Penfield, New York E. Jean Nelson Penfield (1872–1961), American lawyer, parliamentarian Edward Penfield (1866–1925), American illustrator and poster artist Frederic Courtland Penfield (1855–1922), American diplomat Josiah Penfield (1785–1828), American silversmith Roderic C. Penfield (1864–1921), American publisher, printer, editor, journalist, theatre critic, businessman, playwright, and lyricist Samuel Penfield Taylor (1827–1886), American entrepreneur Smith Newell Penfield (1837–1920), American composer Thomas Penfield Jackson (1937–2013), US District Court Judge Wilder Penfield (1891–1976), Canadian neurosurgeon