Gargamel is the villain of the comic strip and animated TV series The Smurfs.
Gargamel may also refer to:
Gargamel!, an American rock band Gargamel, a reggae artist better known as Buju Banton Gargamelle, giantess and mother of Gargantua in Gargantua and Pantagruel Gargamelle, a bubble chamber particle detector at CERN, named for the giantess