Limbic system-associated membrane protein (shortened to LSAMP or LAMP) is a protein which in humans is encoded by the gene LSAMP.
Structure
LSAMP is a 64- to 68-kDa heavily glycosylated protein.
Tissue distribution
LSAMP is found in neurons, specifically it is distributed in cortical and subcortical regions of the limbic system.
Subcellular distribution
LSAMP protein is expressed on the surface of somata and proximal dendrites of neurons where it integrates via glycosyl-phosphatidyl-inositol (GPI) anchor. Despite the name, LSAMP is not expressed only in the limbic-associated areas, but also less intensely in the midbrain and hindbrain regions.
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