Grammatikopoulos (masculine, ) or Grammatikopoulou (feminine, ) is a Greek surname, derived from γραμματέας "grammateas", meaning secretary. Notable people with the surname include:
Achilleas Grammatikopoulos (1908–2008), Greek footballer Panagiotis Grammatikopoulos (born 1959), Greek weightlifter Serafim Grammatikopoulos (born 1960), Greek weightlifter Valentini Grammatikopoulou (born 1997), Greek tennis player