Siani is an Italian surname. Notable people with the surname include:
Alessandro Siani (born 1975), Italian actor, film director, screenwriter and comedian Giancarlo Siani (1959–1985), Italian journalist Giorgio Siani (born 1997), Italian footballer Melvin Siani (born 2004), Canadian football player Mike Siani (American football) (born 1950), American football wide receiver Mike Siani (baseball) (born 1999), American baseball outfielder Sabrina Siani (born 1963), Italian actress Sammy Siani (born 2000), American baseball player Sébastien Siani (born 1986), Cameroonian footballer Valentino Siani (c. 1595 – 1672), Italian luthier