Ruoff is a surname. Notable people with the surname include:
Alex Ruoff (born 1986), American basketball player A. Lavonne Brown Ruoff (born 1930), American writer and academic Bernie Ruoff (born 1951), Canadian football player David Ruoff, American historian and writer Richard Ruoff (1883–1967), German general Rodney S. Ruoff (born 1957), American physical chemist and nanoscience researcher