121 may refer to:

121 (number), the natural number following 120 and preceding 122 AD 121, a year in the 2nd century AD 121 BC, a year in the 2nd century BC

121 (Eagle) Sqn, a Royal Air Force aircraft squadron that during the Second World War was one of the three Eagle Squadrons manned by American volunteers Route 121 (MBTA), a bus route in Boston 121 (New Jersey bus), a New Jersey Transit bus route Road 121, see list of highways numbered 121 Russian cruiser Moskva (pennant number: 121) "121", a song by Robert Forster from the album Calling from a Country Phone 121 Hermione, a main-belt asteroid Mazda 121, various models of automobiles produced by Mazda Unit 121 - Hezbollah assassination squad

See also 121st (disambiguation)

12/1 (disambiguation) Unbiunium, a hypothetical chemical element with atomic number 121