The 1959 Cincinnati Bearcats football team represented the University of Cincinnati in the Missouri Valley Conference (MVC) during the 1959 college football season. Led by fifth-year head coach George Blackburn, the Bearcats compiled an overall record of 5–4–1 with a mark of 0–3–1 in conference play, placing last out of five teams in the MVC. The team played home games at Nippert Stadium in Cincinnati.
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