Obaseki is an Edo-language Nigerian surname. Notable people with this surname include:
Agho Obaseki (died 1920), Benin leader Andrews Otutu Obaseki (1926–2017), Nigerian jurist Darlington Obaseki (born 1968), Nigerian professor Gaius Obaseki, Nigerian politician Godwin Obaseki (born 1957), Nigerian politician Matilda Obaseki, Nigerian actress