Kankan Region () is a region of Guinea located in the east of the country. It is the largest region of Guinea by area, covering an area of 72,145 km2; and it had a population of 4,110,215 at the Census on 1 July 2025. The region is divided into five prefectures (Kankan, Kérouané, Kouroussa, Mandiana and Siguiri).

It is bordered by the countries of Mali and Côte d'Ivoire and the Guinean regions of Nzérékoré and Faranah.

Administrative divisions Kankan Region is divided into five prefectures; which are further sub-divided into 58 sub-prefectures:

Prefecture Capital Land Area(km2) Population2014 Census Population2025 Census Number ofSub-prefectures Kankan Prefecture Kankan 19,750473,359 841,969 13 Kérouané Prefecture Kérouané 7,020207,547297,935 8 Kouroussa Prefecture Kouroussa 14,050 268,630 451,20512 Mandiana Prefecture Mandiana 12,825335,999 800,959 12 Siguiri Prefecture Siguiri 18,500687,002 1,718,147 13

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