D12 is an American hip-hop group originating from Detroit, Michigan.

D12 may also refer to:

Military transport ARA Heroína (D-12), a 1983 Argentine Navy MEKO 360H2 series destroyer Albatros D.XII, a 1918 German single-seat fighter biplane Pfalz D.XII, a 1918 German fighter aircraft HMS Striker (D12), a 1942 British converted aircraft carrier D-12 Almirante Clemente, a Venezuelan Navy Almirante Clemente class destroyer D-12 armoured car, a Soviet military vehicle of the early 1930s Dewoitine D.12, a French fighter aircraft

Civilian transport Spyker D12, a luxury vehicle made by Dutch car company Spyker Bavarian D XII, an 1897 German steam locomotive model Curtiss D-12, a 1923 aircraft engine GS&WR Class D12, a Great Southern and Western Railway Irish steam locomotive

Other uses A nickname for DirecTV-12, a DirecTV satellite D12, part of the Allis-Chalmers D Series of tractors A nickname for NBA All-Star Dwight Howard, whose jersey number is 12 d12, a twelve-sided polyhedral die used in many games Dublin 12, a postal district of Dublin, Ireland Familial adenomatous polyposis, a cancerous condition (ICD-10 code: D12) Acronym for Double 12, mean two tanks with 12 liter in Scuba diving D12, the eldest eaglet from the 2012 clutch of the Decorah Bald Eagles D12 road (Croatia), a state road in central Croatia DVCPRO HD (D-12), a professional digital high definition video format