The Charolais-Brionnais region () is located in the southwest of the French department of Saône-et-Loire, in Burgundy. Created in 2004, the region comprises a population of 90,000 inhabitants across 129 municipalities.

Geography The Charolais-Brionnais region is home to the renowned Charolais cattle and is an applicant for UNESCO status as a World Heritage Site to preserve, consolidate and transmit this resource.

The Loire River, flanked by its adjoining canals, flows on the western edge of Charolais-Brionnais. The EuroVelo long-distance cycling route EV6, also named the Rivers Route, leaves the Loire at Digoin for the Canal du Centre, where it starts its way through the Charolais.

The Charolais-Brionnais was awarded with two food certifications of the European Union (protected designation of origin; ) for AOP Charolles Beef and AOP Charolais Goat Cheese.

Noteworthy landmarks and towns Paray-le-Monial, nicknamed the city of the Sacred Heart Charolles, nicknamed the Venice of the Charolais Bourbon-Lancy, a spa town with a 2,000-year history La Clayette and its 14th- and 19th-century castle Semur-en-Brionnais and its 9th-century castle, one of the oldest in Burgundy

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