Gafencu is a Romanian surname that may refer to:
Eduard Gafencu (born 1993), Romanian kickboxer and boxer Grigore Gafencu (1892–1957), Romanian politician, diplomat, and journalist Liliana Gafencu (born 1975), Romanian rower Valeriu Gafencu (1921–1952), Romanian Orthodox theologian and Legionnaire Vasile Gafencu (1886–1942), Bessarabian politician