James Creek is a third-order tributary to the Little River in Hoke and Moore Counties, North Carolina.

Course James Creek rises on the Jennie Creek divide about one mile south of Southern Pines in Moore County, North Carolina. James Creek then flows northeasterly to meet the Little River about two miles northeast of Inverness.

Watershed James Creek drains of area, receives about 47.8 in/year of precipitation, has a topographic wetness index of 456.69 and is about 55% forested.

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