Moutoussamy is a surname. Notable people with the surname include:
Ernest Moutoussamy (born 1941), French politician John Moutoussamy (1922-1995), African-American architect Lea Moutoussamy, Algerian fencer Samuel Moutoussamy (born 1996), French footballer Thierry Moutoussamy (born 1972), French musician, known as Lord Kossity