Irala is a surname of Basque origin. Notable people with the surname include:
Adriano Irala (1894–1933), Paraguayan professor and journalist Blas Irala (born 1983), Paraguayan footballer Casimiro Abdon Irala Arguello (born 1936), Brazilian Jesuit priest and musician Domingo Martínez de Irala (1509–1556), Spanish conquistador Padre Irala (1936–2024), Paraguayan-Brazilian Jesuit priest, writer, musician and songwriter Pedro Richard Irala (born 1979), Paraguayan footballer Severiano Irala (died 2012), Paraguayan footballer
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