Tsosie is a surname, derived from the Navajo word , meaning "slender" or "slim" and may refer to:
Ernie Tsosie, half of the Navajo comedy duo James & Ernie Krystal Tsosie, Navajo geneticist Leonard Tsosie (born 1955), American politician Myron Tsosie, American politician Rebecca Tsosie, American jurist Ellavina Tsosie Perkins (born 1940), Navajo linguist Steven Tsosie Plummer (1944-2005), first Navajo bishop of the Episcopal Church Frank Tsosie Thompson (1920-2008), Navajo code talker