Wolfen may refer to:
Places Wolfen, Germany, town in Saxony-Anhalt
Fiction The Wolfen, 1978 horror novel by Whitley Strieber Wolfen (film), 1981 horror film
Gaming An enemy in Kya: Dark Lineage Wolfen, the ships used by the Star Wolf team in the Star Fox series A species of wolf-like humanoids in Rackham's Cadwallon role-playing game and Confrontation miniatures game
Other uses ORWO, (Original Wolfen), a brand of photographic films